How can a genetic score be used to measure CAD risk?

Quantifying the genetic risk of CAD using a genetic score can also be used to study the connection between CAD and other traits on the basis of genetics.

What is genotype-based CAD risk prediction?

The ultimate goal of genotype-based CAD risk prediction is to improve upon the discrimination and stratification offered by conventional risk factors alone. Genotype-based CAD risk prediction may eventually have clinical utility, but not without intrinsic complexities.

Is CAD genetic?

The past decade of research has provided a broader understanding of the genetic architecture of CAD and demonstrates that the genetic basis of CAD largely derives from the cumulative effect of multiple common risk alleles individually of small effect size rather than rare variants with large effects on CAD risk.

How has technology changed the genetics of CAD & other complex diseases?

Recent progress in understanding the genetics of CAD and other complex diseases has been driven by technological advances, including high-throughput DNA microarray technology using chips containing up to a million DNA markers consisting of single-nucleotide polymorphisms (SNPs).